The Garcea laboratory studies the structure and assembly of small DNA viruses, with emphasis on polyoma and papillomaviruses. Current interests are:
  1. the mechanism of mitogenic signal transduction initiated by the interaction of viral capsid proteins with cell surface gangliosides, and
  2. the sites of virion assembly in the nucleus and the cellular proteins that mediate genome packaging.

In addition, structural studies of human papillomavirus (HPV) have led to translational research concerning the development of next generation HPV vaccines using capsid subunits (capsomeres) that are purified after bacterial expression of the L1 viral coat protein. The laboratory therefore offers an environment for both basic and translational research, with opportunities for graduate students, post-doctoral fellows, and clinical fellows.